Abuse-related effects of subtype-selective GABAA receptor positive allosteric modulators in an assay of intracranial self-stimulation in rats

摘要

RationaleGABAA Positive Allosteric Modulators (GABAA PAMs), such as diazepam and zolpidem, are used clinically for anxiety and insomnia, but abuse-liability is a concern. Novel GABAA PAMS may have lower abuse-liability while retaining clinical utility.