Pd-Catalyzed Acyl C–O Bond Activation for Selective Ring-opening of α-Methylene-β-lactones with Amines

摘要

A Pd-catalyzed ring-opening of β-lactones with various types of amines (primary, secondary and aryl) to provide β-hydroxy amides with excellent selectivity towards acyl C–O bond cleavage is reported. The utility of this protocol is demonstrated in an asymmetric kinetic resolution providing enantioenriched α-Methylene-β-lactones