DEVELOPMENTALLY REGULATED ALTERNATIVE SPLICING IS PERTURBED IN TYPE 1 DIABETIC SKELETAL MUSCLE

摘要

IntroductionType 1 diabetic patients can develop skeletal muscle weakness and atrophy by molecular mechanisms that are not well understood. Alternative splicing (AS) is critical for gene expression in the skeletal muscle, and its dysregulation is implicated in muscle weakness and atrophy. Therefore, we investigated whether AS patterns are affected in type 1 diabetic skeletal muscle contributing to skeletal muscle defects.