Conditioned Taste Avoidance Conditioned Place Preference and Hyperthermia induced by the Second Generation ‘Bath Salt’ α-pyrrolidinopentiophenone (α-PVP)

摘要

Backgroundα-pyrrolidinopentiophenone (α-PVP) has been reported to be rewarding in a variety of pre-clinical models. Given that a number of drugs of abuse have both rewarding and aversive effects, the balance of which influences addiction potential, the present study examined the aversive properties of α-PVP by assessing its ability to induce taste avoidance. This assessment was made in a combined taste avoidance/place conditioning design that also allowed an evaluation of the relationship between α-PVP’s aversive and rewarding effects.