Biomedical Informatics Approaches to Identifying Drug-Drug Interactions: Application to Insulin Secretagogues

摘要

BackgroundDrug-drug interactions with insulin secretagogues are associated with increased risk of serious hypoglycemia in patients with type 2 diabetes. We aimed to systematically screen for drugs that interact with the five most commonly used secretagogues―glipizide, glyburide, glimepiride, repaglinide, and nateglinide―to cause serious hypoglycemia.