Verbenanone an octahydro-5H-chromen-5-one from a Hawaiian-Plant Associated Fungus FT431

摘要

A new secondary metabolite verbenanone (>1) with a unique (4aS,8aS)-octahydro-5H-chromen-5-one moiety has been obtained from the endophytic fungus FT431, which was isolated from the native Hawaiian plant Verbena sp. The structure of compound >1 was characterized based on NMR and MS spectroscopic analysis. The absolute configuration (AC) of compound >1 was determined by Mosher acids. Compound >1 was tested against A2780 and A2780cisR, but it was inactive.