Electrotaxis of Cardiac Progenitor Cells Cardiac Fibroblasts and Induced Pluripotent Stem cell-derived Cardiac Progenitor Cells requires serum and is directed via PI3′K pathways

摘要

BackgroundThe limited regenerative capacity of cardiac tissue has long been an obstacle to treating damaged myocardium. Cell-based therapy offers an enormous potential to the current treatment paradigms. However, the efficacy of regenerative therapies remains limited by inefficient delivery and engraftment. Electrotaxis, electrically guided cell movement, has been clinically utilized to improve recovery in a number of tissues, but has not been investigated for treating myocardial damage.