EFFICACY OF SKIN MOISTURIZER WITH ADVANCED CERAMIDE AND FILAGGRIN TECHNOLOGY IN CHINESE ELDERLY

摘要

Chronic itch is a common health problem in the elderly, frequently associated with skin dryness. However, it is often the case that little attention is paid to skin care until scratching due to itch damages skin and leads to inflammatory lesions that need medical treatments. A pilot study was conducted in China to test the efficacy in the elderly of an easy-to-do skin care regimen with moisturizer that was developed using advanced ceramide and filaggrin technology. A total of 60 volunteers (26 males and 34 females, 72.6 +/- 8.7 years of age) with moderate dry skin and itch participated in the study and experienced a 2-week self-treatment with moisturizer and body wash. The change in skin dryness severity, itch severity, and quality of life (day- and night-time) was assessed 1 and 2 weeks after the initiation of treatment. As a result, all of skin dryness, itch, and quality of life rapidly improved at 1 week and further improved at 2 weeks with statistical significance compared to the baseline (P<0.001). The acceptability questionnaire completed by the participants at the end of the study showed their high satisfaction with the regimen. One case of contact dermatitis was reported and no other treatment-related adverse events occurred. In conclusion, this result provides evidence that the skin care regimen tested in this study is effective in the elderly, not only on skin dryness or itch but also on the quality of life, with a good tolerability and acceptability.