ARTERIAL STIFFNESS A CHOICE MAKER OF THE CARDIOVASCULAR TREATMENT AT ELDERLY WITH DIABETES

摘要

>Introduction: Previous research has indicated that treatment with more than one antihypertensive medication class is related to elevated levels of PWV. The aim of the study was to follow the link of antihypertensive treatment and arterial stiffness at elderly with diabetes. >Methods: 143 participans were included; 81.2% female and 18.8% males; mean age was 72.28 ± 10.098 years. Parameters of arterial stiffness aPWV were measured using an oscillometric device (Arteriograph) in addition to a medical history, physical examination, and laboratory tests. Depending on the diagnosis of diabetes we have 2 groups. >Results: Age is positively correlated with Aortic PWV (r=0.65, p<0.001) and also brachial augmentation index (p=0.02) but not with diabetes. We observe a high rate of 28% converting enzyme inhibitor used in people with diabetes. The proportion of diuretic class exceeds 16% in diabetic patients compared with 10% in those without diabetes (p=0.020). Diabetic patients appear to be more educated on the importance of treatment, 61% of them constantly taking him to those without diabetes. Those with uncontrolled blood pressure group presents a mean aortic pulse wave velocity statistically significantly higher (Student t-test, p=0.043). We see a lower PWV on those who have diuretic treatment (17%). >Conclusions: The evaluation of arterial stiffness represents a valuable tool for elderly with diabetes. It should be noted that the effects of pharmacologic agents on stiffness are slight or modest, but not substantial and new therapeutic approaches to decrease arterial stiffness are needed.