首页> 美国卫生研究院文献>other >LiGa5O8:Cr-based theranostic nanoparticles for imaging-guided X-ray induced photodynamic therapy of deep-seated tumors
【2h】

LiGa5O8:Cr-based theranostic nanoparticles for imaging-guided X-ray induced photodynamic therapy of deep-seated tumors

机译:LiGa5O8:Cr基治疗性纳米粒子用于影像引导下的X射线诱导的深部肿瘤光动力疗法

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务,本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文,但由于OA文献来源多样且变更频繁,仍可能出现获取不到、文献不完整或与标题不符等情况,如果获取不到我们将提供退款服务。请知悉。

摘要

Using X-ray as the irradiation source, a photodynamic therapy process can be initiated from under deep tissues. This technology, referred to as X-ray induced PDT, or X-PDT, holds great potential to treat tumors at internal organs. To this end, one question is how to navigate the treatment to tumors with accuracy with external irradiation. Herein we address the issue with a novel, LiGa5O8: Cr (LGO:Cr)-based nanoscintillator, which emits persistent, near-infrared X-ray luminescence. This permits deep-tissue optical imaging that can be employed to guide irradiation. Specifically, we encapsulated LGO:Cr nanoparticles and a photosensitizer, 2,3-naphthalocyanine, into mesoporous silica nanoparticles. The nanoparticles were conjugated with cetuximab and systemically injected into H1299 orthotopic non-small cell lung cancer tumor models. The nanoconjugates can efficiently home to tumors in the lung, confirmed by monitoring X-ray luminescence from LGO:Cr. Guided by the imaging, external irradiation was applied, leading to efficient tumor suppression while minimally affecting normal tissues. To the best of our knowledge, the present study is the first to demonstrate, with systematically injected nanoparticles, that X-PDT can suppress growth of deep-seated tumors. The imaging guidance is also new to X-PDT, and is significant to the further transformation of the technology.
机译:使用X射线作为照射源,可以从深层组织下面开始光动力治疗过程。这项技术被称为X射线诱导的PDT或X-PDT,在治疗内部器官肿瘤方面具有巨大潜力。为此,一个问题是如何利用外部照射准确地将治疗导引至肿瘤。在这里,我们用一种新颖的基于LiGa5O8:Cr(LGO:Cr)的纳米闪烁体来解决这个问题,该闪烁体发出持续的近红外X射线发光。这允许可用于引导辐射的深部组织光学成像。具体而言,我们将LGO:Cr纳米颗粒和光敏剂2,3-萘酞菁包封到中孔二氧化硅纳米颗粒中。将纳米颗粒与西妥昔单抗缀合并全身注射到H1299原位非小细胞肺癌肿瘤模型中。通过监测LGO:Cr的X射线发光证实,纳米复合物可以有效地归巢于肺部肿瘤。在成像的指导下,应用外部照射,从而有效地抑制了肿瘤,同时对正常组织的影响最小。据我们所知,本研究是第一个通过系统注射纳米颗粒来证明X-PDT可以抑制深部肿瘤生长的研究。成像指导对于X-PDT也是新的,对技术的进一步转变具有重要意义。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号