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Urokinase-type plasminogen activator receptor (uPAR) tissue factor (TF) and epidermal growth factor receptor (EGFR): tumor expression patterns and prognostic value in oral cancer

机译:尿激酶型纤溶酶原激活剂受体(uPAR)组织因子(TF)和表皮生长因子受体(EGFR):口腔癌的肿瘤表达模式和预后价值

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摘要

BackgroundTumor-specific biomarkers are a prerequisite for the development of targeted imaging and therapy in oral squamous cell carcinoma (OSCC). urokinase-type Plasminogen Activator Receptor (uPAR), Tissue Factor (TF) and Epidermal Growth Factor Receptor (EGFR) are three biomarkers that exhibit enhanced expression in many types of cancers, and have been investigated as potential biomarkers for targeted strategies and prognostication. The aim of the study was to investigate the expression patterns of uPAR, TF and EGFR and their potential prognostic value in OSCC.
机译:背景肿瘤特异性生物标志物是口腔鳞状细胞癌(OSCC)靶向成像和治疗发展的先决条件。尿激酶型纤溶酶原激活物受体(uPAR),组织因子(TF)和表皮生长因子受体(EGFR)是三种生物标志物,在许多类型的癌症中均表现出增强的表达,并已被研究为靶向策略和预后的潜在生物标志物。该研究的目的是研究uPAR,TF和EGFR的表达模式及其在OSCC中的预后价值。

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