Diminished Medial Prefrontal Cortex Activation During the Recollection of Stressful Events is an Acquired Characteristic of PTSD

摘要

BackgroundPrevious research has shown relatively diminished medial prefrontal cortex activation and heightened psychophysiological responses during the recollection of personal events in posttraumatic stress disorder (PTSD), but the origin of these abnormalities is unknown. Twin studies provide the opportunity to determine whether such abnormalities reflect familial vulnerabilities, result from trauma exposure, or are acquired characteristics of PTSD.