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In vivo magnetic resonance images reveal neuroanatomical sex differences through the application of voxel-based morphometry in C57BL/6 mice

机译:体内磁共振图像通过基于体素的形态计量学在C57BL / 6小鼠中的应用揭示了神经解剖学上的性别差异

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摘要

Behaviorally relevant sex differences are often associated with structural differences in the brain and many diseases are sexually dimorphic in prevalence and progression. Characterizing sex differences is imperative to gaining a complete understanding of behavior and disease which will, in turn, allow for a balanced approach to scientific research and the development of therapies. In this study, we generated novel tissue probability maps (TPMs) based on 30 male and 30 female in vivo C57BL/6 mouse brain magnetic resonance images and used voxel-based morphometry (VBM) to analyze sex differences. Females displayed larger anterior hippocampus, basolateral amygdala, and lateral cerebellar cortex volumes, while males exhibited larger cerebral cortex, medial amygdala, and medial cerebellar cortex volumes. Atlas-based morphometry (ABM) revealed a statistically significant sex difference in cortical volume and no difference in whole cerebellar volume. This validated our VBM findings that showed a larger cerebral cortex in male mice and a pattern of dimorphism in the cerebellum where the lateral portion was larger in females and the medial portion was larger in males. These results are consonant with previous ex vivo studies examining sex differences, but also suggest further regions of interest.
机译:与行为相关的性别差异通常与大脑的结构差异有关,许多疾病的患病率和进展呈性别二态。刻画性别差异对全面了解行为和疾病至关重要,这反过来又可以使科学研究和治疗方法的平衡成为可能。在这项研究中,我们基于30位男性和30位女性体内C57BL / 6小鼠大脑磁共振图像生成了新颖的组织概率图(TPM),并使用了基于体素的形态计量学(VBM)来分析性别差异。雌性显示较大的前海马,基底外侧杏仁核和小脑外侧皮质体积,而雄性则显示较大的大脑皮层,内侧杏仁核和小脑内侧皮质体积。基于Atlas的形态计量学(ABM)显示,皮质体积的性别差异具有统计学意义,而整个小脑体积没有差异。这证实了我们的VBM发现,该发现显示雄性小鼠的大脑皮层更大,小脑的双态性模式,雌性的外侧部分较大,雄性的内侧部分较大。这些结果与先前的研究性别差异的离体研究相吻合,但也提示了更多感兴趣的领域。

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