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Tree based weighted learning for estimating individualized treatment rules with censored data

机译:基于树的加权学习用于估计带有审查数据的个性化治疗规则

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摘要

Estimating individualized treatment rules is a central task for personalized medicine. [] and [] proposed outcome weighted learning to estimate individualized treatment rules directly through maximizing the expected outcome without modeling the response directly. In this paper, we extend the outcome weighted learning to right censored survival data without requiring either inverse probability of censoring weighting or semiparametric modeling of the censoring and failure times as done in []. To accomplish this, we take advantage of the tree based approach proposed in [] to nonparametrically impute the survival time in two different ways. The first approach replaces the reward of each individual by the expected survival time, while in the second approach only the censored observations are imputed by their conditional expected failure times. We establish consistency and convergence rates for both estimators. In simulation studies, our estimators demonstrate improved performance compared to existing methods. We also illustrate the proposed method on a phase III clinical trial of non-small cell lung cancer.
机译:估计个性化治疗规则是个性化医学的核心任务。 []和[]提出了结果加权学习,以通过最大化预期结果直接估计个性化治疗规则,而无需直接对响应进行建模。在本文中,我们将结果加权学习扩展到正确的审查生存数据,而无需审查权重的反概率或审查和失败时间的半参数建模,如[]所述。为此,我们利用[]中提出的基于树的方法以两种不同方式非参数地估算生存时间。第一种方法用预期生存时间代替每个人的报酬,而在第二种方法中,仅受检查的观测值由其有条件的预期失效时间来估算。我们为两个估计量建立一致性和收敛速度。在仿真研究中,我们的估算器证明了与现有方法相比性能得到改善。我们还说明了在非小细胞肺癌的III期临床试验中提出的方法。

著录项

  • 期刊名称 other
  • 作者单位
  • 年(卷),期 -1(11),2
  • 年度 -1
  • 页码 3927–3953
  • 总页数 33
  • 原文格式 PDF
  • 正文语种
  • 中图分类
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