Don’t let sleeping dogmas lie: New views of peptidoglycan synthesis and its regulation

摘要

The cell wall is an essential component of most bacterial cells, and has been a major focus of research for the last 50 years. Despite this intense research, we still have an incomplete understanding of how bacteria construct their cell wall. In this MicroReview, we will summarize important new data generated in the last few years, reexamine some established ideas in the field, and propose a new model of cell wall biogenesis in rod-shaped bacteria.