Novel Bis-Cyclic Guanidines as Potent Membrane-Active Antibacterial Agents with Therapeutic Potential

摘要

We designed a class of small dimeric cyclic guanidine derivatives, which display potent antibacterial activity against both multidrug-resistant Gram-negative and Gram-positive bacteria. They could compromise bacterial membranes without developing resistance, inhibit biofilms formed by E. Coli, and exhibit excellent in vivo activity in the MRSA-infected thigh burden mouse model.