Pharmacoimaging of Blood-Brain Barrier Permeable (FDG) and Impermeable (FLT) Substrates After Intranasal (IN) Administration

摘要

PurposeTo illustrate the use of imaging to quantify the transfer of materials from the nasal cavity to other anatomical compartments, specifically, transfer to the brain using the thymidine analogue, [¹⁸F]fluorothymidine (FLT), and the glucose analogue, [¹⁸F]fluorodeoxyglucose (FDG).