Characterizing the Subjective Observer-rated and Physiological Effects of Hydromorphone Relative to Heroin in a Human Laboratory Study

摘要

BackgroundThis study compared the effects of the several doses of the opioid agonists heroin and hydromorphone across two routes of administration in humans. The goal was to guide development of human laboratory studies of opioid effects and inform subsequent injection pharmacotherapy trials of hydromorphone-assisted treatment.