Enhanced Molecular Typing of Treponema pallidum subsp. pallidum strains from four Italian hospitals shows geographical differences in strain type heterogeneity widespread resistance to macrolides and lack of mutations associated with doxycycline resistance

摘要

BackgroundAlthough syphilis rates have been relatively high in Italy for over 15 years, no data on the molecular types of Treponema pallidum subsp. pallidum (T. pallidum) circulating in this country are yet available. Likewise, no data exist on how widespread is resistance to macrolide or tetracycline antibiotics in these strains. Such data would however promote comprehensive studies on the molecular epidemiology of syphilis infections in Italy and inform future interventions aiming at syphilis control in this and other European countries.