The Effects of Testosterone Replacement on Self-reported and Performance-based Measures of Mobility in Older Men with Mobility Limitation and Low Testosterone Levels: A Placebo-Controlled Trial

摘要

BackgroundWe report detailed results of The Physical Function Trial (PFT), one of seven Testosterone Trials (TTrials), which determined testosterone’s effects on mobility, self-reported physical function, falls, and patient global impression-of-change (PGIC) in older men with self-reported mobility limitation and walking speed<1.2 m/sec. We determined if testosterone’s effects on mobility differed according to baseline walking speed, mobility-limitation, or other participant-level factors.