PATH-14. SURGICAL STRATEGY FOR LOWER GRADE GLIOMAS USING INTRAOPERATIVE RAPID MOLECULAR AND PATHOLOGICAL DIAGNOSIS

摘要

INTRODUCTIONIn the 2016 WHO classification, genetic information was introduced in the pathological diagnosis of gliomas, and the correlation between molecular subtype and prognosis has been shown. High extent of removal (EOR) provides survival benefit for some subtype of lower grade gliomas (LGGs), but it is often difficult to achieve both high EOR and preservation of brain function. Our institute has been working on intraoperative rapid molecular diagnosis of LGGs using HRM method for IDH mutation and immunostaining of p53/ATRX for 1p/19q codeletion for an intraoperative decesion making. We report the clinical results of patients with LGGs treated in our facility and discuss the significance of the surgical strategy based on intraoperative rapid molecular diagnosis.