CBMT-15. METABOLIC AND TRANSCRIPTIONAL PROFILES OF GBM INVASION: COMPARISON OF PATIENTS AND PAIRED PATIENT DERIVED XENOGRAFTS USING1H MAGNETIC RESONANCE SPECTROSCOPY AND IMAGING (7T AND 14T) AND RNA-SEQUENCING

摘要

BACKGROUNDGlioblastoma (GBM) are notorious for their invasive behavior. Little is known about the biology of the tumor cells and the microenvironment at the invasive front that is highly relevant for recurrence. These cells are technically difficult to visualize, lie usually outside the resected and irradiated area, and are behind the blood brain barrier that renders them difficult to treat. We present patient specific metabolic and transcriptomic features of invasive growth using corresponding patient derived xenografts (PDX).