The diagnostic accuracy and clinical utility of paediatric renal tumour biopsy – report of the UK experience in the SIOP UK WT 2001 trial

摘要

IntroductionThe International Society of Paediatric Oncology (SIOP) protocols recommend pre-operative chemotherapy appropriate for Wilms tumours (WT) in children with renal tumours aged ≥6 months, reserving biopsy for ‘atypical’ cases. The Children’s Cancer and Leukaemia Group (CCLG) joined the SIOP-WT-2001 study but continued the national practice of biopsy at presentation.