Dipeptidyl peptidase-4 inhibitors as add-on therapy to insulin in patients with type 2 diabetes mellitus: a meta-analysis of randomized controlled trials

机译：二肽基肽酶-4抑制剂作为2型糖尿病患者胰岛素的附加治疗：一项随机对照试验的荟萃分析

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摘要

PurposeAddition of the dipeptidyl peptidase-4 (DPP4) inhibitors to insulin in patients with type 2 diabetes mellitus (T2DM) may achieve better glycemic control. However, results of pilot randomized controlled trials (RCTs) are inconsistent. We aimed to perform a meta-analysis of RCTs to evaluate efficacy and safety of DPP4 inhibitors compared with placeboo treatment as add-on therapy to insulin in T2DM patients.

机译：目的在2型糖尿病（T2DM）患者中，在胰岛素中添加二肽基肽酶4（DPP4）抑制剂可实现更好的血糖控制。但是，试点随机对照试验（RCT）的结果不一致。我们的目标是进行RCT的荟萃分析，以评估DPP4抑制剂与T2DM患者胰岛素作为安慰剂的补充治疗相比的疗效和安全性。

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期刊名称 Diabetes Metabolic Syndrome and Obesity: Targets and Therapy
作者
Na Wang; Tao Yang; Jie Li; Xianfeng Zhang;
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作者单位

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年(卷),期 2019(12),-1
年度 2019
页码 1513–1526
总页数 14
原文格式 PDF
正文语种
中图分类基础医学;
关键词
dipeptidyl peptidase-4 inhibitors insulin add-on therapy diabetes mellitus meta-analysis;

机译：二肽基肽酶4抑制剂;胰岛素;附加疗法;糖尿病;荟萃分析;

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专利

1. Dipeptidyl peptidase-4 inhibitors as add-on therapy to insulin in patients with type 2 diabetes mellitus: a meta-analysis of randomized controlled trials [J] . Na Wang, Tao Yang, Jie Li, Diabetes, metabolic syndrome and obesity: targets and therapy . 2019,第3a2期

机译：二肽基肽酶-4抑制剂作为2型糖尿病患者胰岛素的附加治疗：一项随机对照试验的荟萃分析
2. Efficacy and safety of initial combined therapy with metformin plus a dipeptidyl peptidase-4 inhibitor versus metformin monotherapy in type 2 diabetes mellitus: a systematic review and meta-analysis of phase 3 randomised controlled trials [J] . Tangney N., De Buitleir C., OBrien T., Irish journal of medical science . 2019,第Suppla9期

机译：初始联合治疗与二甲双胍加二肽基肽酶-4抑制剂对二甲双胍单疗法2型糖尿病的疗效和安全性：第3期随机对照试验的系统回顾和荟萃分析
3. Short-term and long-term effects of dipeptidyl peptidase-4 inhibitors in type 2 diabetes mellitus patients with renal impairment: a meta-analysis of randomized controlled trials [J] . Diabetes/metabolism research and reviews . 2016,第6期

机译：二肽基肽酶-4抑制剂在2型糖尿病肾功能不全患者中的短期和长期作用：一项随机对照试验的荟萃分析
4. Fragment-Based Drug Design to Discover Novel Inhibitor of Dipeptidyl Peptidase-4 (DPP-4) as a Potential Drug for Type 2 Diabetes Therapy [C] . Eka Gunarti Ningsih, Muhammad Fauzi Hidayat, Usman Sumo Friend Tambunan International work-conference on bioinformatics and biomedical engineering . 2019

机译：基于片段的药物设计，发现二肽基肽酶-4（DPP-4）的新型抑制剂作为2型糖尿病治疗的潜在药物
5. A 4-month randomized controlled clinical trial of adjuvant Exenatide or Pramlintide versus insulin alone in pediatric type 1 diabetes mellitus: Effect on glycemic control. [D] . Withycombe, Sarah Elizabeth. 2010

机译：儿科1型糖尿病患者中艾塞那肽或普兰林肽与单独使用胰岛素的4个月随机对照临床试验：对血糖控制的影响。
6. Head-to-Head Comparison of the Hypoglycemic Efficacy and Safety Between Dipeptidyl Peptidase-4 Inhibitors and α-Glucosidase Inhibitors in Patients With Type 2 Diabetes Mellitus: A Meta-Analysis of Randomized Controlled Trials [O] . Zhaoliang Li, Liang Zhao, Leilei Yu, 2019

机译：二肽肽酶-4型糖尿病患者二肽肽酶-4抑制剂和α-葡萄糖苷酶抑制剂的低血糖疗效和安全性的头脑比较：随机对照试验的荟萃分析
7. Head-to-Head Comparison of the Hypoglycemic Efficacy and Safety Between Dipeptidyl Peptidase-4 Inhibitors and α-Glucosidase Inhibitors in Patients With Type 2 Diabetes Mellitus: A Meta-Analysis of Randomized Controlled Trials [O] . Zhaoliang Li, Liang Zhao, Leilei Yu, 2019

机译：二肽肽酶-4型糖尿病患者二肽肽酶-4抑制剂和α-葡萄糖苷酶抑制剂的低血糖疗效和安全性的头脑比较：随机对照试验的荟萃分析

Dipeptidyl peptidase-4 inhibitors as add-on therapy to insulin in patients with type 2 diabetes mellitus: a meta-analysis of randomized controlled trials

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