Enhancement of the Antitumor Effect by Combined Use of High‐energy Shock Waves and ATX‐70

摘要

The antitumor effects of high‐energy shock waves (HESW) in combination with ATX‐70 [a gallium‐porphyrin complex, 2,4‐bis(1‐decyloxyethyl)‐Ga(III)‐1,3,5,8‐tetramethylporphyrin‐6,7‐dipropionyi diaspartic acid] were investigated. In vitro, the cell damage to mouse MH134 hepatoma after HESW treatment was enhanced by adding ATX‐70. In vivo, HESW and ATX‐70 combination therapy inhibited cell growth. However, neither HESW treatment alone nor ATX‐70 treatment alone inhibited cell growth. These results imply that the antitumor effects of HESW and ATX‐70 combined therapy are caused by activation of ATX‐70 by HESW.