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美国卫生研究院文献>The Journal of Physiology
>Increased activity of pre-motor network does not change the excitability of motoneurons during protracted scratch initiation
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Increased activity of pre-motor network does not change the excitability of motoneurons during protracted scratch initiation
Intrinsic response properties of neurons change during network activity. These changes may reinforce the initiation of particular forms of network activity. If so, the involvement of neurons in particular behaviours in multifunctional networks could be determined by up- or down-regulation of their intrinsic excitability. Here we employed an experimental paradigm of protracted scratch initiation in the integrated carapace–spinal cord preparation of adult turtles (Chrysemys scripta elegans). The protracted initiation of scratch network activity allows us to investigate the excitability of motoneurons and pre-motor network activity in the time interval from the start of sensory stimulation until the onset of scratch activity. Our results suggest that increased activity in the pre-motor network facilitates the onset of scratch episodes but does not change the excitability of motoneurons at the onset of scratching.
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机译:神经元的内在反应特性会在网络活动期间发生变化。这些更改可能会增强特定形式的网络活动的启动。如果是这样,则可以通过上调或下调神经元的内在兴奋性来确定其参与多功能网络中特定行为的过程。在这里,我们在成年乌龟(Chrysemys scripta elegans)的甲壳-脊髓整合体中采用了持久的从头开始的实验范式。从头开始长期的刮擦网络活动使我们能够研究从感觉刺激开始到刮擦活动开始的时间间隔内运动神经元的兴奋性和运动前网络活动。我们的结果表明,运动前网络中活动的增加促进了刮擦发作的发生,但是在刮擦开始时不会改变运动神经元的兴奋性。
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