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Intranasal influenza vaccination using a new synthetic mucosal adjuvant SF‐10: induction of potent local and systemic immunity with balanced Th1 and Th2 responses

机译：使用新型合成粘膜佐剂SF-10进行鼻内流感疫苗接种：诱导有效的局部和全身免疫并平衡Th1和Th2反应

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BackgroundWe found previously that bovine pulmonary Surfacten^® used in newborns with acute respiratory distress syndrome is a safe and efficacious antigen vehicle for intranasal vaccination.

机译：背景我们以前发现，用于患有急性呼吸窘迫综合征的新生儿的牛肺Surfacten ^{®是用于鼻内疫苗接种的安全有效的抗原载体。}

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期刊名称 Influenza and Other Respiratory Viruses
作者
Takashi Kimoto; Dai Mizuno; Tsunetomo Takei; Takuya Kunimi; Shinji Ono; Satoko Sakai; Hiroshi Kido;
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作者单位

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年(卷),期 2013(7),6
年度 2013
页码 1218–1226
总页数 9
原文格式 PDF
正文语种
中图分类病毒传染病;人体病毒学（致病病毒）;病毒（滤过性病毒）;
关键词
influenza vaccine nasal vaccination Pulmonary surfactant synthetic mucosal adjuvant Th1/Th2 responses;

机译：流感疫苗;鼻腔疫苗接种;肺表面活性剂;合成粘膜佐剂;Th1 / Th2反应;

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专利

1. Intranasal influenza vaccination using a new synthetic mucosal adjuvant SF-10: Induction of potent local and systemic immunity with balanced Th1 and Th2 responses [J] . KimotoT., MizunoD., TakeiT., Influenza and other respiratory viruses. . 2013,第6期

机译：使用新型合成粘膜佐剂SF-10进行鼻内流感疫苗接种：诱导具有平衡的Th1和Th2反应的强力局部和全身免疫
2. Intranasal influenza vaccination using a new synthetic mucosal adjuvant SF‐10: induction of potent local and systemic immunity with balanced Th1 and Th2 responses [J] . Dai Mizuno, Satoko Sakai, Shinji Ono, Influenza and other respiratory viruses. . 2013,第6期

机译：使用新型合成粘膜佐剂SF-10进行鼻内流感疫苗接种：诱导有效的局部和全身免疫，并平衡Th1和Th2反应
3. Induction of systemic and mucosal immunity and maintenance of its memory against influenza A virus by nasal vaccination using a new mucosal adjuvant SF-10 derived from pulmonary surfactant in young cynomolgus monkeys [J] . Mizuno Dai, Kimoto Takashi, Sakai Satoko, Vaccine . 2016,第16期

机译：在幼食猕猴中使用新的肺表面活性物质黏膜佐剂SF-10进行鼻腔接种，通过鼻疫苗诱导全身和黏膜免疫，并保持其对甲型流感病毒的记忆
4. Intranasal vaccination with a lipopeptide containing a minimal, conserved M-protein derived peptide and a self-adjuvanting lipid induces both systemic and mucosal immune responses in mice [C] . Michael R. Batzloff, Jon Hartas, Weiguang Zeng, Lancefield International Symposium on Streptococci and Streptococcal Diseases . 2006

机译：用含有最小，保守的M蛋白衍生的肽和自佐剂脂质的脂肽接种疫苗接种诱导小鼠的全身和粘膜免疫应答
5. Modulation of the immune response at systemic and mucosal sites by DNA vaccine adjuvants in HIV and influenza models. [D] . Kraynyak, Kimberly Ann. 2009

机译：DNA疫苗佐剂在HIV和流感模型中对全身和粘膜部位免疫应答的调节。
6. Intranasal DNA Vaccination Induces Potent Mucosal and Systemic Immune Responses and Cross-protective Immunity Against Influenza Viruses [O] . Lea Torrieri-Dramard, Bénédicte Lambrecht, Helena Lage Ferreira, 2011

机译：鼻内DNA疫苗接种可诱导强大的粘膜和全身免疫反应以及针对流感病毒的交叉保护性免疫
7. Induction of systemic and mucosal immunity and maintenance of its memory against influenza A virus by nasal vaccination using a new mucosal adjuvant SF-10 derived from pulmonary surfactant in young cynomolgus monkeys [O] . Mizuno Dai, Kimoto Takashi, Sakai Satoko, 2016

机译：在幼食猕猴中使用新的肺表面活性物质粘膜佐剂SF-10鼻腔接种疫苗，通过鼻疫苗诱导全身和粘膜免疫，并保持其对甲型流感病毒的记忆

Intranasal influenza vaccination using a new synthetic mucosal adjuvant SF‐10: induction of potent local and systemic immunity with balanced Th1 and Th2 responses

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