Striatal activity and reduced white matter increase frontal activity in youths with family histories of alcohol and other substance-use disorders performing a goo-go task

摘要

IntroductionYouths with a family history of alcohol and other drug use disorders (FH+) are at greater risk of developing substance-use disorders relative to those with no such family histories (FH−). We previously reported that FH+ youths have elevated activity in the supplementary motor area (SMA) and dorsal striatum while performing goo-go tasks and have reduced frontal white matter integrity. A better understanding of relationships between these variables would provide insight into how frontostriatal circuitry is altered in FH+ youths, which may be an important contributor to their elevated risk.