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Depleted aldehyde dehydrogenase 1A1 (ALDH1A1) reverses cisplatin resistance of human lung adenocarcinoma cell A549/DDP

机译：枯竭的醛脱氢酶1A1（ALDH1A1）逆转人肺腺癌细胞A549 / DDP的顺铂耐药性

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BackgroundCisplatin is the standard first‐line chemotherapeutic agent for the treatment of non‐small cell lung cancer (NSCLC). However, resistance to chemotherapy has been a major obstacle in the management of NSCLC. Aldehyde dehydrogenase 1A1 (ALDH1A1) overexpression has been observed in a variety of cancers, including lung cancer. The purpose of this study was to investigate the effect of ALDH1A1 expression on cisplatin resistance and explore the mechanism responsible.

机译：背景顺铂是用于治疗非小细胞肺癌（NSCLC）的标准一线化疗药物。但是，对化疗的耐药性一直是非小细胞肺癌治疗的主要障碍。醛脱氢酶1A1（ALDH1A1）的过表达已在包括肺癌在内的多种癌症中被观察到。这项研究的目的是调查ALDH1A1表达对顺铂耐药性的影响，并探讨其机制。

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期刊名称 Thoracic Cancer
作者
Yunyan Wei; Shuangshuang Wu; Wei Xu; Yan Liang; Yue Li; Weihong Zhao; Jianqing Wu;
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作者单位

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年(卷),期 2017(8),1
年度 2017
页码 26–32
总页数 7
原文格式 PDF
正文语种
中图分类肿瘤学;
关键词
Aldehyde dehydrogenase 1A1 apoptosis cisplatin resistance non‐small cell lung cancer proliferation;

机译：醛脱氢酶1A1;凋亡;顺铂耐药;非小细胞肺癌;增殖;

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专利

1. Depleted aldehyde dehydrogenase 1A1 (ALDH1A1) reverses cisplatin resistance of human lung adenocarcinoma cell A549/DDP [J] . Wei Yunyan, Wu Shuangshuang, Xu Wei, Thoracic cancer. . 2017,第1期

机译：枯竭的醛脱氢酶1A1（ALDH1A1）逆转人肺腺癌细胞A549 / DDP的顺铂耐药性
2. Depleted Aldehyde Dehydrogenase1A1 Reverses Cisplatin Resistance of Non-small Cell Lung Cancer Cells A549/DDP [J] . Wei Y. Y., Wu S. S., Xu W., Journal of the American Geriatrics Society . 2015,第Suppla2期

机译：耗尽的醛脱氢酶1A1逆转非小细胞肺癌细胞A549 / DDP的顺铂耐药性。
3. Promoter methylation profiles between human lung adenocarcinoma multidrug resistant A549/cisplatin (A549/DDP) cells and its progenitor A549 cells [J] . Guo R., Wu G., Li H., Biological & pharmaceutical bulletin . 2013,第8期

机译：人肺腺癌多药耐药A549 /顺铂（A549 / DDP）细胞与其祖先A549细胞之间的启动子甲基化分布
4. The effect of ammonium chloride on the apoptosis induced by cisplatin in human lung cancer A549 cells [C] . Ye Xu, Ning Wang, Yan Ding, International Forum on Materials Science and Industrial Technology . 2013

机译：氯化铵对人肺癌顺铂诱导凋亡的影响A549细胞
5. Yu Ping Feng San, an Ancient Chinese Herbal Decoction, Reverses Cisplatin-Induced Multi-Drug Resistance in Lung Cancer Cells: Mechanistic Evaluation and Development of New Formula [D] . Lou, Jianshu 2018

机译：俞平风散，一种古老的中药汤剂，逆转顺铂诱导的肺癌细胞多药耐药性：新药的机械评价和开发
6. The CK2 inhibitor CX4945 reverses cisplatin resistance in the A549/DDP human lung adenocarcinoma cell line [O] . Chengji Jin, Ping Song, Ji Pang -1

机译：CK2抑制剂CX4945逆转A549 / DDP人肺腺癌细胞系中的顺铂耐药性
7. Depleted aldehyde dehydrogenase 1A1 (ALDH1A1) reverses cisplatin resistance of human lung adenocarcinoma cell A549/DDP [O] . Yunyan Wei, Shuangshuang Wu, Wei Xu, 2016

机译：耗尽醛脱氢酶1A1（ALDH1A1）反转人肺腺癌细胞A549 / DDP的顺铂抗性

Depleted aldehyde dehydrogenase 1A1 (ALDH1A1) reverses cisplatin resistance of human lung adenocarcinoma cell A549/DDP

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