Remote Limb Ischemic Preconditioning Attenuates Cerebrovascular Depression During Sinusoidal Galvanic Vestibular Stimulation via α1‐Adrenoceptor–Protein Kinase Cε–Endothelial NO Synthase Pathway in Rats

摘要

BackgroundVasovagal syncope (VVS) is characterized by hypotension and bradycardia followed by lowering of cerebral blood flow. Remote limb ischemic preconditioning (RIPC) is well documented to provide cardio‐ and neuroprotection as well as to improve cerebral blood flow. We hypothesized that RIPC will provide protection against VVS‐induced hypotension, bradycardia, and cerebral hypoperfusion. Second, because endothelial nitric oxide synthase has been reported as a mediator of cerebral blood flow control, we hypothesized that the mechanism by which RIPC primes the vasculature against VVS is via the α1‐adrenoceptor–protein kinase Cε–endothelial nitric oxide synthase pathway.