Production and separation of 43Sc for radiopharmaceutical purposes

摘要

BackgroundThe favorable decay properties of ⁴³Sc and ⁴⁴Sc for PET make them promising candidates for future applications in nuclear medicine. An advantage ⁴³Sc (T1/2 = 3.89 h, Eβ⁺ av = 476 keV [88%]) exhibits over ⁴⁴Sc, however, is the absence of co-emitted high energy γ-rays. While the production and application of ⁴⁴Sc has been comprehensively discussed, research concerning ⁴³Sc is still in its infancy. This study aimed at developing two different production routes for ⁴³Sc, based on proton irradiation of enriched ⁴⁶Ti and ⁴³Ca target material.