Enhanced Potency and Durability of Antibody Response to Seasonal Trivalent Inactivated Influenza Vaccine (TIV) Combined with a Novel Water-in-Oil Adjuvant System at Reduced Hemagglutinin (HA) Doses

摘要

BackgroundNew influenza vaccines are needed to increase vaccine efficacy against infection and illness. Adjuvants may allow HA dose-sparing while increasing the antibody response. MAS-1 is an investigational low viscosity, free-flowing, water-in-oil emulsion-based adjuvant delivery system with stable nanoglobular droplets whether manufactured in bulk or at point-of-use (POU). MAS-1 oily vehicle is stable for at least 5 years at room temperature, in bulk or POU vials.