Rapid Identification of Gram-Negative Bacteremia and Impact on Anti-Pseudomonal Antibiotic Consumption in Combination with Antibiotic Stewardship at a Community-Based Hospital System

摘要

BackgroundRapid diagnostics for blood cultures have shown to decrease unnecessary antibiotics; however, this has mostly been studied in gram-positive organisms. The Verigene Gram-Negative Blood Culture Test (BC-GN) identifies eight bacteria at species/genus level and six resistance genes, detected 2 hours from a positive blood culture. By identifying the gram-negative (GN) pathogen earlier compared with traditional methodology, there is the potential to decrease broad spectrum antibiotic utilization. The purpose of this study was to determine the impact of Verigene BC-GN with antibiotic stewardship on anti-pseudomonal (AP) antibiotic consumption in GN bacteremia among pathogens when AP therapy is not needed. Based on local susceptibility data, this included Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytoca, and Proteus spp.