Time estimations by network of beta globin gene cluster haplotypes linked with Hb D‐Los Angeles β121 (GH4) Glu → Gln GAA → CAA mutation in the world populations

摘要

Backgroundβ‐Globin gene cluster haplotypes associated with the Hb D‐Los Angeles mutation have been reported in many different locations in different populations including Italy, Iran, Thailand, Belgium, Mexico, Holland, and Turkey. In this study, we have identified genetic relationships and formation periods between the haplotypes reported in the world regarding the Hb D‐Los Angeles.