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Novel concept to guide systolic heart failure medication by repeated biomarker testing—results from TIME-CHF in context of predictive preventive and personalized medicine

机译：通过重复的生物标志物测试指导收缩性心力衰竭药物治疗的新概念-TIME-CHF在预测性预防性和个性化医学的背景下得出的结果

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摘要

BackgroundIt is uncertain whether repeated measurements of a multi-target biomarker panel may help to personalize medical heart failure (HF) therapy to improve outcome in chronic HF.

机译：背景不确定多目标生物标志物面板的重复测量是否有助于个性化医疗心力衰竭（HF）治疗以改善慢性HF的预后。

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期刊名称 The EPMA Journal
作者
Nasser Davarzani; Sandra Sanders-van Wijk; Micha T. Maeder; Peter Rickenbacher; Evgueni Smirnov; Joël Karel; Thomas Suter; Rudolf A. de Boer; Dirk Block; Vinzent Rolny; Christian Zaugg; Matthias E. Pfisterer; Ralf Peeters; Hans-Peter Brunner-La Rocca;
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年(卷),期 2018(9),2
年度 2018
页码 161–173
总页数 13
原文格式 PDF
正文语种
中图分类
关键词
Heart failure Biomarker Heart failure medication Predictive preventive personalized medicine Generalized estimating equations;

机译：心力衰竭;生物标志物;心力衰竭药物;预测性预防性个性化药物;广义估计方程;

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1. Novel concept to guide systolic heart failure medication by repeated biomarker testing—results from TIME-CHF in context of predictive, preventive, and personalized medicine [J] . Nasser Davarzani, Sandra Sanders-van Wijk, Micha T. Maeder, The EPMA journal. . 2018,第2期

机译：通过重复的生物标志物测试指导收缩性心力衰竭药物治疗的新概念-TIME-CHF在预测性，预防性和个性化医学的背景下得出的结果
2. N-Terminal Pro-B-Type Natriuretic Peptide-Guided Therapy in Chronic Heart Failure Reduces Repeated Hospitalizations - Results From TIME-CHF [J] . Davarzani Nasser, Sanders-Van Wijk Sandra, Karel Joel, Journal of cardiac failure . 2017,第5期

机译：N-末端Pro-B型利钠肽引导治疗慢性心力衰竭减少了重复的住院治疗 - 时间CHF结果
3. BNP-guided vs symptom-guided heart failure therapy: the Trial of Intensified vs Standard Medical Therapy in Elderly Patients With Congestive Heart Failure (TIME-CHF) randomized trial. [J] . Pfisterer M, Buser P, Rickli H, JAMA: the Journal of the American Medical Association . 2009,第4期

机译：BNP指导与症状指导的心力衰竭治疗：老年充血性心力衰竭患者（TIME-CHF）的随机对照试验。
4. Estimation of Heart Failure Patients Medication Adherence through the Utilization of Saliva and Breath Biomarkers and Data Mining Techniques [C] . Evanthia E. Tripoliti, Theofilos G. Papadopoulos, Georgia S. Karanasiou, IEEE International Symposium on Computer-Based Medical Systems . 2017

机译：通过唾液和呼吸生物标记物和数据挖掘技术估算心力衰竭患者的药物依从性
5. The relationships among medication and low-salt diet adherence, beliefs about medicines, and psychosocial variables among individuals with heart failure. [D] . Farrell, Kristen A. 2011

机译：心力衰竭患者中药物与低盐饮食依从性，药物信念以及社会心理变量之间的关系。
6. Assessing value of innovative molecular diagnostic tests in the concept of predictive preventive and personalized medicine [O] . Ildar Akhmetov, Rostyslav V. Bubnov 2015

机译：评估创新性分子诊断测试在预测性预防性和个性化医学概念中的价值
7. HIT Poster session 1P154Preclinical diastolic dysfunction is related to impaired endothelial function in patients with chronic kidney diseaseP155Early detection of left atrial and left ventricular abnormalities in hypertensive and obese womenP156Right ventricle preserved systolic function irrespective of right ventricular hypertrophy and disease severity in anderson fabry diseaseP157Left atrial volume and function in patients undergoing percutaneous mitral valve repairP158Impact of left ventricular dysfunction on outcomes of patients undergoing direct TAVI with a self-expanding bioprosthesisP159Anatomic Doppler spectrum – retrospective spectral tissue Doppler from ultra high frame rate tissue Doppler imaging for evaluation of tissue deformationP160Phasic dynamics of ischaemic mitral regurgitation after primary coronary intervention in acute myocardial infarction: serial echocardiographic assessment from emergency room to long-term follow-upP161Reproducibility of 3DE RV volumes - novel insights at a regional levelP162Pulmonary vascular capacitance as assessed by echocardiography in pulmonary arterial hypertensionP163Three-dimensional endocardial area strain: a novel parameter for quantitative assessment of global left ventricular systolic functionP164Role of exercise hemodynamics assessed by echocardiography on symptom reduction after MitraClipP165Early identification of ventricular dysfunction in patients with juvenile systemic sclerosisP166Heart failure with and without preserved ejection fraction - the role of biomarkers in the aspect of global longitudinal strainP167Complex systolic deformation of aortic root: insights from two dimensional speckle tracking imageP168Volumetric and deformational imaging usind 2d strain and 3d echocardiography in patients with pulmonary hypertensionP169Influence of pressure load and right ventricular morphology and function on tricuspid regurgitation in pulmonary arterial hypertensionP170Left ventricular myocardial diastolic deformation analysis by 2D speckle tracking echocardiography and relationship with conventional diastolic parameters in chronic aortic regurgitationP171Extracellular volume, and not native T1 time, distinguishes diffuse fibrosis in dilated or hypertrophic cardiomyopathy at 3TP172Left atrial strain is significantly reduced in arterial hypertensionP173Symptomatic severe secondary mitral regurgitation: LV enddiastolic diameter (LVEDD) as preferable parameter for risk stratificationP174Left ventricular mechanics in isolated left bundle branch block at rest and when exercising: exploration of the concept of conductive cardiomyopathyP175Assessment of myocardial scar by 2D contrast echocardiographyP176Chronic pericarditis - expression of a rare disease: Erdheim Chester diseaseP177Aortic arch mechanics with two-dimensional speckle tracking echocardiography to estimate the left ventricular remodelling in hypertensive patientsP178Strain analysis by tissue doppler imaging: comparison of conventional manual measurement with a semi-automated approachP179Distribution of extravascular lung water in heart failure patients assessed by lung ultrasoudP180Surrogate markers for obstructive coronary artery diseaseP181LA deformation and LV longitudinal strain by two-dimensional speckle tracking echocardiography as predictors of postoperative AF development after aortic valve replacement in ASP182Left ventricular diastolic dysfunction in type 2 diabetic patients with non alcoholic fatty liver diseaseP183Myocardial strain by speckle-tracking and evaluation of 3D ejection fraction in drug-induced cardiotoxicity's approach in breast cancer [O] . AB Gevaert, A Borizanova, F Graziani, 2015

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8. Heart Failure: Evaluation and Care of Patients with Left-Ventricular Systolic Dysfunction. Clinical Practice Guideline No. 11; Heart Failure: Management of Patients with Left-Ventricular Systolic Dysfunction. Quick Reference Guide for Clinicians No. 11; Living with Heart Disease: Is It Heart Failure. Patient and Family Guide [R] . 1994

机译：心力衰竭：左心室收缩功能障碍患者的评估和护理。临床实践指南第11号;心力衰竭：左心室收缩功能障碍患者的治疗。临床医生快速参考指南第11号;与心脏病共存：是心衰吗？患者和家庭指南

Novel concept to guide systolic heart failure medication by repeated biomarker testing—results from TIME-CHF in context of predictive preventive and personalized medicine

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