Uniform intratumoral distribution of radioactivity produced using two different radioagents 64Cu-cyclam-RAFT-c(-RGDfK-)4 and 64Cu-ATSM improves therapeutic efficacy in a small animal tumor model

摘要

BackgroundThe present study proposed a new concept for targeted radionuclide therapy (TRT) to improve the intratumoral distribution of radioactivity using two different radiopharmaceuticals. We examined the efficacy of a combination of a tetrameric cyclic Arg-Gly-Asp (cRGD) peptide-based radiopharmaceutical, ⁶⁴Cu-cyclam-RAFT-c(-RGDfK-)4 (⁶⁴Cu-RaftRGD, an αVβ3 integrin [αVβ3] tracer), and ⁶⁴Cu-diacetyl-bis (N⁴-methylthiosemicarbazone) (⁶⁴Cu-ATSM, a supposed tracer for hypoxic metabolism) in a small animal tumor model.