S132. A NORMATIVE CHART FOR THE TRAJECTORY OF COGNITIVE FUNCTIONING IN INDIVIDUALS AT HIGH RISK FOR SCHIZOPHRENIA: LONGITUDINAL FINDINGS FROM THE INTERNATIONAL BRAIN AND BEHAVIOR CONSORTIUM ON 22Q11.2 DELETION SYNDROME

摘要

BackgroundIn schizophrenia, a decline in cognitive functioning often precedes the onset of the first psychotic episode by many years. We have previously shown this to be the case for individuals with 22q11.2 deletion syndrome (22q11DS), a genetic variant associated with a 20–25% risk of developing schizophrenia. We also observed that, regardless of the subsequent development of psychosis, individuals with 22q11DS show, on average a modest decline in IQ between 8 and 24 years and that in those who develop a psychotic disorder this decline follows a steeper trajectory. The tendency for a modest cognitive decline may represent a cognitive phenotype that is specific to 22q11DS, and possibly, an endophenotype for schizophrenia in this population. In order to assess this, we constructed a normative chart for cognitive development over time in individuals with 22q11DS.