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Effect of Solution pH on Distribution of Ophthalmically Administered Brimonidine in Posterior Ocular Tissues in Pigmented Rabbits

机译：溶液pH值对色素兔眼后组织眼用溴莫尼定分布的影响。

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IntroductionBrimonidine bioavailability in the aqueous humor depends on the solution pH following topical administration. The purpose of this study was to investigate the effect of solution pH on brimonidine distribution in the posterior ocular tissues in pigmented rabbits.

机译：简介溴莫尼定在房水中的生物利用度取决于局部给药后溶液的pH值。这项研究的目的是研究溶液pH对有色兔子后眼组织中溴莫尼定分布的影响。

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期刊名称 Ophthalmology and Therapy
作者
Keisuke Shinno; Kazuya Kurokawa; Seiko Kozai; Akio Kawamura; Katsuhiro Inada; Hideki Tokushige;
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作者单位

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年(卷),期 2019(8),2
年度 2019
页码 271–277
总页数 7
原文格式 PDF
正文语种
中图分类眼科学;
关键词
Brimonidine Distribution Penetration route Pharmacokinetics Retina/choroid Vitreous body;

机译：溴莫尼定;分布;渗透途径;药代动力学;视网膜/脉络膜;玻璃体;

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1. Effect of Solution pH on Distribution of Ophthalmically Administered Brimonidine in Posterior Ocular Tissues in Pigmented Rabbits [J] . Keisuke Shinno, Kazuya Kurokawa, Seiko Kozai, Ophthalmology and therapy. . 2019,第2期

机译：溶液pH值对色素兔眼后组织眼用溴莫尼定分布的影响。
2. Comparative efficacy study of brimonidine tartrate 0.15% and timolol maleate 0.5% ophthalmic solution (benzalkonium chloride free) versus Brimolol? (with benzalkonium chloride) following single ocular instillation in New Zealand white rabbits [J] . Amit Thavkar, Sateesh Kumar Chauhan, Subhas Bhowmick, International Journal of Basic & Clinical Pharmacology . 2020,第7期

机译：对比疗效研究双羟胺酸碱0.15％和蒂莫尔马来酸的0.5％眼科溶液（无苯并氯化氢）与Brimolol？（用苯并氯化铵）在新西兰白兔的单眼滴注后
3. Ocular pharmacokinetics and tolerability of bimatoprost ophthalmic solutions administered once or twice daily in rabbits, and clinical dosing implications [Corrigendum] [J] . Shen J, Goodkin ML, Tong W, Clinical ophthalmology . 2018,第4期

机译：每天在兔中施用一次或两次的双踪药代动力学和耐受性，临床给药影响[逆变]
4. 28-day ocular delivery of brimonidine tartrate from rationally designed degradable microparticles in a rabbit model [C] . Morgan V. Fedorchak, Jeremy Wingard, Carlos Medina, Society for Biomaterials fall symposium 2012.;vol. 34. . 2012

机译：合理设计的可降解微粒在兔模型中的酒石酸溴莫尼定的28天眼部给药
5. Mechanisms and Effects of Femtosecond Laser Micromachining in Ophthalmic Materials and Ocular Tissue [D] . Yu, Dan. 2021

机译：飞秒激光微机制在眼科材料和眼组织中的机制和影响
6. Ocular pharmacokinetics and tolerability of bimatoprost ophthalmic solutions administered once or twice daily in rabbits and clinical dosing implications Corrigendum [O] . 2018

机译：每天一次或两次在兔子中施用比马前列素眼用溶液的眼药代动力学和耐受性以及对临床剂量的影响勘误
7. Effect of Solution pH on Distribution of Ophthalmically Administered Brimonidine in Posterior Ocular Tissues in Pigmented Rabbits [O] . Keisuke Shinno, Kazuya Kurokawa, Seiko Kozai, 2019

机译：溶液pH对色素兔后眼组织在眼科施用的吡啶胺分布的影响

Effect of Solution pH on Distribution of Ophthalmically Administered Brimonidine in Posterior Ocular Tissues in Pigmented Rabbits

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