A 6-year Prospective Observational Multi-Center Post-Marketing Surveillance of the Safety of Tetanus Toxoid Reduced Diphtheria Toxoid and Acellular Pertussis (Tdap) Vaccine in Korea

摘要

BackgroundIncidence of whooping cough is increasing in Korea. Since 2011, occurrence among adolescents and adults has risen putting vulnerable neonates at risk. National immunization guidelines now include Tdap (tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis) vaccination during pregnancy and as a cocooning strategy (i.e., vaccinating adults and adolescents in contact with neonates). This study assessed post-marketing Tdap (Boostrix®, GSK, Belgium) vaccine safety in subjects ≥ 10 years.