A Randomized Double-Blind Placebo- and Active Comparator-Controlled Phase I Study of Analgesic/Antihyperalgesic Properties of ASP8477 a Fatty Acid Amide Hydrolase Inhibitor in Healthy Female Subjects

机译：脂肪酸酰胺水解酶抑制剂ASP8477在健康女性受试者中的镇痛/抗痛觉过敏特性的随机双盲安慰剂和活性比较剂控制的I期研究

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摘要

ObjectivesTo evaluate the analgesic/antihyperalgesic effect of ASP8477.

机译：目的评估ASP8477的镇痛/抗痛觉过敏作用。

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期刊名称 Pain Medicine: The Official Journal of the American Academy of Pain Medicine
作者
Klaus Schaffler; Ashraf Yassen; Peter Reeh; Paul Passier;
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作者单位

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年(卷),期 -1(19),6
年度 -1
页码 1206–1218
总页数 13
原文格式 PDF
正文语种
中图分类基础医学;
关键词
ASP8477 FAAH Duloxetine Neuropathic Pain LEP VAS;

机译：ASP8477;FAAH;度洛西汀;神经性疼痛;LEP;VAS;

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专利

1. A Randomized, Double-Blind, Placebo- and Active Comparator-Controlled Phase I Study of Analgesic/Antihyperalgesic Properties of ASP8477, a Fatty Acid Amide Hydrolase Inhibitor, in Healthy Female Subjects [J] . Schaffler Klaus, Yassen Ashraf, Reeh Peter, Pain medicine : . 2018,第6期

机译：ASP8477中ASP8477的镇痛/抗震性能，脂肪酸酰胺水解酶抑制剂，在健康女性受试者中研究随机，双盲，安慰剂和活性比较阶段研究
2. The MOBILE Study-A Phase IIa Enriched Enrollment Randomized Withdrawal Trial to Assess the Analgesic Efficacy and Safety of ASP8477, a Fatty Acid Amide Hydrolase Inhibitor, in Patients with Peripheral Neuropathic Pain [J] . Bradford Daniel, Stirling Anjali, Ernault Etienne, Pain medicine : . 2017,第12期

机译：移动研究 - 一种相位性IIA富集的入学率随机戒断试验，以评估患有外周神经病疼痛的患者脂肪酸酰胺水解酶抑制剂ASP8477的镇痛功效和安全性
3. A Phase I, Randomized, Double-Blind, Laser-Evoked Potential Study to Evaluate the Analgesic/Antihyperalgesic Effect of ASP9226, a State-Dependent N-Type Voltage-Gated Calcium Channel Inhibitor, in Healthy Male Subjects [J] . Schaffler Klaus, He Weizhong, Passier Paul, Pain medicine : . 2018,第11期

机译：I阶段，随机，双盲，激光诱发的潜在研究，以评估ASP9226，一种状态依赖性N型电压钙通道抑制剂，健康男性受试者的镇痛/抗震术效果
4. A Phase I, Double-Blind, Randomized, Dose Escalating Crossover Study ofan Oral Formulation of Human Growth Hormone in Healthy Male Volunteers [C] . Steven M. Dinh, Puchun Liu, Ehud Arbit, Controlled Release Society annual meeting . 2004

机译：健康男性志愿者中人类生长激素口服制剂的I期，双盲，随机，剂量递增交叉研究
5. I. Optimization and analysis of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase. II. Total synthesis of chloropeptin II (complestatin) and progress towards a second generation total synthesis of chloropeptin I and II. [D] . Garfunkle, Joie. 2009

机译：I.脂肪酸酰胺水解酶的α-酮杂环抑制剂中心杂环的优化和分析。二。氯肽II（complestatin）的全合成，并向第二代氯肽I和II的全合成方向发展。
6. The MOBILE Study—A Phase IIa Enriched Enrollment Randomized Withdrawal Trial to Assess the Analgesic Efficacy and Safety of ASP8477 a Fatty Acid Amide Hydrolase Inhibitor in Patients with Peripheral Neuropathic Pain [O] . Daniel Bradford, Anjali Stirling, Etienne Ernault, -1

机译：MOBILE研究—一项IIa期临床试验旨在评估脂肪酸酰胺水解酶抑制剂ASP8477在周围神经性疼痛患者中的镇痛效果和安全性
7. 1645. Exploring Clinical and Antiviral Efficacy of Baloxavir Marboxil in a Phase 3, Randomized, Double-Blind, Placebo- and Active-Controlled Study of Otherwise Healthy Adults/Adolescents in Seasonal Influenza: Impact on Regional Participants, Treatment Time and Influenza Type B Virus Infection (CAPSTONE-1 Study) [O] . Keiko Kawaguchi, Simon Portsmouth, Takao Shishido, 2018

机译：1645.在季节性流感中探讨Baboxavir Marboxil的临床和抗病毒疗效，在季节性流感的其他健康成人/青少年的临床和抗病毒疗效：对区域参与者的影响，治疗时间和流感B病毒感染（Capstone-1研究）

A Randomized Double-Blind Placebo- and Active Comparator-Controlled Phase I Study of Analgesic/Antihyperalgesic Properties of ASP8477 a Fatty Acid Amide Hydrolase Inhibitor in Healthy Female Subjects

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