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Trapping/Pinning of colloidal microspheres over glass substrate using surface features

机译:使用表面特征在玻璃基板上捕获/固定胶体微球

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摘要

Suspensions of microano particles made of Polystyrene, Poly(methyl methacrylate), Silicon dioxide etc. have been a standard model system to understand colloidal physics. These systems have proved useful insights into phenomena such as self-assembly. Colloidal model systems are also extensively used to simulate many condensed matter phenomena such as dynamics in a quenched disordered system and glass transition. A precise control of particles using optical or holographic tweezers is essential for such studies. However, studies of collective phenomena such as jamming and flocking behaviour in a disordered space are limited due to the low throughput of the optical trapping techniques. In this article, we present a technique where we trap and pin polystyrene microspheres ~10 μm over ‘triangular crest’ shaped microstructures in a microfluidic environment. Trapping/Pinning occurs due to the combined effect of hydrodynamic interaction and non-specific adhesion forces. This method allows trapping and pinning of microspheres in any arbitrary pattern with a high degree of spatial accuracy which can be useful in studying fundamentals of various collective phenomena as well as in applications such as bead detachment assay based biosensors.
机译:由聚苯乙烯,聚甲基丙烯酸甲酯,二氧化硅等制成的微/纳米颗粒的悬浮液已成为理解胶体物理学的标准模型系统。这些系统已证明对诸如自组装等现象很有用。胶体模型系统还广泛用于模拟许多冷凝物现象,例如淬火无序系统中的动力学和玻璃化转变。对于此类研究,使用光学或全息镊子精确控制颗粒至关重要。然而,由于光学陷波技术的低通量,对诸如无序空间中的堵塞和植绒行为等集体现象的研究受到限制。在本文中,我们介绍了一种在微流体环境中将聚苯乙烯微球捕获并钉扎在“三角波峰”形状的微结构上约10μm的技术。由于流体动力相互作用和非特异性粘附力的共同作用,发生陷印/固定。该方法允许以高度的空间精度以任意模式捕获和固定微球,这对于研究各种集体现象的基础以及诸如基于珠子分离测定的生物传感器等应用很有用。

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