This study demonstrated that the vitamin D3 decomposition product VDP1 exerts an antibacterial action against Helicobacter pylori but not against other bacteria. Treatment with VDP1 induced a collapse of cell membrane structures of H. pylori and ultimately lysed the bacterial cells. A unique dimyristoyl phosphatidylethanolamine in the membrane lipid compositions contributed to the interaction of VDP1 with H. pylori cells. In separate experiments, VDP1 had no influence on the viability of the human cancer cell lines MKN45 and T47D and lacked any vitamin D3-like hormonal action against the latter. In both 1H and 13C NMR analyses, the spectra patterns of VDP1 corresponded with those of Grundmann's ketone. These results suggest that VDP1 (or Grundmann's ketone-type indene compound) may become a fundamental structure for the development of new antibacterial substances with selective bactericidal action against H. pylori.
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机译：这项研究表明，维生素D3分解产物VDP1对幽门螺杆菌具有抗菌作用，而对其他细菌则没有。用VDP1处理诱导幽门螺杆菌的细胞膜结构崩溃，并最终裂解细菌细胞。膜脂质组合物中独特的二肉豆蔻酰基磷脂酰乙醇胺促进了VDP1与幽门螺杆菌细胞的相互作用。在单独的实验中，VDP1对人癌细胞系MKN45和T47D的生存力没有影响，并且缺乏针对后者的任何类似于维生素D3的激素作用。在 1 H和 13 C NMR分析中，VDP1的光谱图与Grundmann酮的光谱图相对应。这些结果表明，VDP1（或Grundmann的酮型茚化合物）可能成为开发新的对幽门螺杆菌具有选择性杀菌作用的抗菌物质的基本结构。
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