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Optical Magnetic Induction Tomography of the Heart

机译:心脏的光磁感应断层扫描

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摘要

Atrial Fibrillation (AF) affects a significant fraction of the ageing population, causing a high level of morbidity and mortality. Despite its significance, the causes of AF are still not uniquely identified. This, combined with the lack of precise diagnostic and guiding tools, makes the clinical treatment of AF sub-optimal. We identify magnetic induction tomography as the most promising technique for the investigation of the causes of fibrillation and for its clinical practice. We therefore propose a novel optical instrument based on optical atomic magnetometers, fulfilling the requirements for diagnostic mapping of the heart’s conductivity. The feasibility of the device is here discussed in view of the final application. Thanks to the potential of atomic magnetometers for miniaturisation and extreme sensitivity at room temperature, a new generation of compact and non-invasive diagnostic instrumentation, with both bedside and intra-operative operation capability, is envisioned. Possible scenarios both in clinical practice and biomedical research are then discussed. The flexibility of the system makes it promising also for application in other fields, such as neurology and oncology.
机译:心房颤动(AF)影响着大部分人口的老龄化,从而导致很高的发病率和死亡率。尽管有重要意义,但房颤的病因仍未得到唯一鉴定。再加上缺乏精确的诊断和指导工具,使得房颤的临床治疗效果欠佳。我们认为磁感应断层扫描是最有前途的技术,用于调查原纤维形成的原因及其临床实践。因此,我们提出了一种基于光学原子磁力计的新型光学仪器,可满足诊断心脏电导率的要求。鉴于最终应用,在此讨论该设备的可行性。由于原子磁力计具有在室温下实现小型化和极高灵敏度的潜力,因此可以设想具有床边和术中操作能力的新一代紧凑型无创诊断仪器。然后讨论了临床实践和生物医学研究中可能出现的情况。该系统的灵活性使其也有望在其他领域中应用,例如神经病学和肿瘤学。

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