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Relationship of corneal hysteresis and optic nerve parameters in healthy myopic subjects

机译:健康近视患者角膜滞后与视神经参数的关系

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摘要

The association between corneal biomechanical properties and glaucoma is an area of much interest. We determined the relationship between corneal hysteresis (CH) and optic nerve parameters in healthy myopic subjects in the current study. CH was measured with Reichert Ocular Response Analyzer in 108 eyes from 108 healthy myopic subjects. All subjects received retinal nerve fiber layer and optic disc imaging Cirrus HD-OCT, GDx ECC, and Heidelberg Retina Tomograph II. None of the tested optic nerve parameters showed statistical significance with CH by using correlation analysis. For RNFL parameters, there was a negative but not statistically significant correlation between CH and average RNFL thickness obtained with OCT (r = −0.15, p = 0.13). For optic disc parameters, there was a negative but not statistically significant correlation between CH and rim area measured with OCT (r = −0.10, p = 0.29). The current study did not find any statistically significant relationship between CH and optic nerve parameters as measured by all three imaging modalities in healthy myopic eyes. Therefore, the relationship observed previously in glaucoma subjects is likely coming to fruition as optic nerve damage is caused by the disease.
机译:角膜生物力学性质与青光眼之间的关联是一个令人关注的领域。在本研究中,我们确定了健康近视受试者的角膜滞后(CH)与视神经参数之间的关系。用Reichert眼部反应分析仪对来自108位健康近视受试者的108只眼睛的CH进行了测量。所有受试者均接受了视网膜神经纤维层和视盘成像Cirrus HD-OCT,GDx ECC和Heidelberg Retina Tomograph II。通过使用相关分析,所有测试的视神经参数均未显示出CH的统计学意义。对于RNFL参数,CH和OCT获得的平均RNFL厚度之间存在负相关但在统计学上无显着相关性(r = -0.15,p = 0.13)。对于视盘参数,用OCT测得的CH和边缘区域之间存在负相关但无统计学意义(r = -0.10,p = 0.29)。当前的研究没有发现在健康的近视眼中,通过所有三种成像方式所测量的CH和视神经参数之间存在统计学上的显着关系。因此,先前在青光眼受试者中观察到的这种关系很可能成为现实,因为该疾病引起了视神经损伤。

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