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A whole-body Fast Field-Cycling scanner for clinical molecular imaging studies

机译:用于临床分子成像研究的全身快速场循环扫描仪

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摘要

Fast Field-Cycling (FFC) is a well-established Nuclear Magnetic Resonance (NMR) technique that exploits varying magnetic fields to quantify molecular motion over a wide range of time scales, providing rich structural information from nanometres to micrometres, non-invasively. Previous work demonstrated great potential for FFC-NMR biomarkers in medical applications; our research group has now ported this technology to medical imaging by designing a whole-body FFC Magnetic Resonance Imaging (FFC-MRI) scanner capable of performing accurate measurements non-invasively over the entire body, using signals from water and fat protons. This is a unique tool to explore new biomarkers related to disease-induced tissue remodelling. Our approach required making radical changes in the design, construction and control of MRI hardware so that the magnetic field is switched within 12.5 ms to reach any field strength from 50 μT to 0.2 T, providing clinically useful images within minutes. Pilot studies demonstrated endogenous field-dependant contrast in biological tissues in good agreement with reference data from other imaging modalities, confirming that our system can perform multiscale structural imaging of biological tissues, from nanometres to micrometres. It is now possible to confirm ex vivo results obtained from previous clinical studies, offering applications in diagnosis, staging and monitoring treatment for cancer, stroke, osteoarthritis and oedema.
机译:快速场循环(FFC)是一种成熟的核磁共振(NMR)技术,它利用变化的磁场来量化大范围时间范围内的分子运动,从而无创地提供了从纳米到微米的丰富结构信息。先前的工作证明了FFC-NMR生物标志物在医学应用中具有巨大潜力;我们的研究小组现在已经通过设计一种全身FFC磁共振成像(FFC-MRI)扫描仪,将该技术应用于医学成像,该扫描仪能够使用水和脂肪质子的信号对整个身体进行无创测量。这是探索与疾病诱导的组织重塑相关的新生物标记的独特工具。我们的方法要求对MRI硬件的设计,构造和控制进行根本性的改变,以使磁场在12.5µms内切换,以达到从50µμT到0.2µT的任何磁场强度,从而在数分钟内提供临床有用的图像。初步研究表明,生物组织中内源性场依赖的对比度与其他成像方式的参考数据非常吻合,从而证实了我们的系统可以对生物组织进行从纳米到微米的多尺度结构成像。现在有可能证实从先前的临床研究中获得的体外结果,可用于癌症,中风,骨关节炎和水肿的诊断,分期和监测治疗。

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