Evaluation of Early Osteochondral Defect Repair in a Rabbit Model Utilizing Fourier Transform–Infrared Imaging Spectroscopy Magnetic Resonance Imaging and Quantitative T2 Mapping

摘要

ContextEvaluation of the morphology and matrix composition of repair cartilage is a critical step toward understanding the natural history of cartilage repair and efficacy of potential therapeutics. In the current study, short-term articular cartilage repair (3 and 6 weeks) was evaluated in a rabbit osteochondral defect model treated with thrombin peptide (TP-508) using magnetic resonance imaging (MRI), quantitative T2 mapping, and Fourier transform–infrared imaging spectroscopy (FT-IRIS).