The Injection of Hypocretin-1 into the Nucleus Pontis Oralis Induces either Active Sleep or Wakefulness Depending on the Behavioral State when it is Administered

摘要

Study Objectives:We previously reported that the microinjection of hypocretin (orexin) into the nucleus pontis oralis (NPO) induces a behavioral state that is comparable to naturally occurring active (rapid eye movement) sleep. However, other laboratories have found that wakefulness occurs following injections of hypocretin into the NPO. The present study tested the hypothesis that the discrepancy in behavioral state responses to hypocretin injections is due to the fact that hypocretin was not administered during the same states of sleep or wakefulness.