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A feasibility study to calculate unshielded fetal doses to pregnant patients in 6-MV photon treatments using Monte Carlo methods and anatomically realistic phantoms

机译:使用蒙特卡洛方法和解剖学上的幻影计算6-MV光子治疗中孕妇的非屏蔽胎儿剂量的可行性研究

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摘要

A Monte Carlo-based procedure to assess fetal doses from 6-MV external photon beam radiation treatments has been developed to improve upon existing techniques that are based on AAPM Task Group Report 36 published in 1995 []. Anatomically realistic models of the pregnant patient representing 3-, 6-, and 9-month gestational stages were implemented into the MCNPX code together with a detailed accelerator model that is capable of simulating scattered and leakage radiation from the accelerator head. Absorbed doses to the fetus were calculated for six different treatment plans for sites above the fetus and one treatment plan for fibrosarcoma in the knee. For treatment plans above the fetus, the fetal doses tended to increase with increasing stage of gestation. This was due to the decrease in distance between the fetal body and field edge with increasing stage of gestation. For the treatment field below the fetus, the absorbed doses tended to decrease with increasing gestational stage of the pregnant patient, due to the increasing size of the fetus and relative constant distance between the field edge and fetal body for each stage. The absorbed doses to the fetus for all treatment plans ranged from a maximum of 30.9 cGy to the 9-month fetus to 1.53 cGy to the 3-month fetus. The study demonstrates the feasibility to accurately determine the absorbed organ doses in the mother and fetus as part of the treatment planning and eventually in risk management.
机译:已经开发出了一种基于蒙特卡洛方法来评估6-MV外部光子束放射治疗的胎儿剂量,以改进基于1995年发布的AAPM任务组报告36的现有技术。代表3、6和9个月妊娠阶段的怀孕患者的解剖学逼真模型与详细的加速器模型一起实现了MCNPX代码,该模型能够模拟来自加速器头的散射和泄漏辐射。针对胎儿上方部位的六种不同治疗方案和膝部纤维肉瘤的一种治疗方案,计算了胎儿的吸收剂量。对于胎儿以上的治疗计划,胎儿剂量倾向于随着妊娠阶段的增加而增加。这是由于随着妊娠阶段的增加,胎儿身体与视野边缘之间的距离减小。对于胎儿以下的治疗区域,由于胎儿的大小增加以及每个阶段的视野边缘与胎儿之间的相对恒定距离,吸收剂量倾向于随着怀孕患者妊娠阶段的增加而降低。所有治疗方案对胎儿的吸收剂量范围从最大30.9 cGy至9个月胎儿至1.53 cGy至3个月胎儿。该研究表明,作为治疗计划的一部分并最终进行风险管理,可以准确确定母亲和胎儿体内吸收的器官剂量。

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