Effects of Switching to the Tobacco Heating System 2.2 Menthol Smoking Abstinence or Continued Cigarette Smoking on Biomarkers of Exposure: A Randomized Controlled Open-Label Multicenter Study in Sequential Confinement and Ambulatory Settings (Part 1)

摘要

IntroductionThe menthol Tobacco Heating System 2.2 (mTHS) is a newly developed candidate modified-risk tobacco product intended to reduce exposure to the harmful and potentially harmful constituents (HPHCs) of conventional cigarette (CC) smoke. This study examined the impact of switching to mTHS on biomarkers of exposure to HPHCs relative to menthol CCs (mCCs) and smoking abstinence (SA).