Effect of everolimus on renal function in patients with tuberous sclerosis complex: evidence from EXIST-1 and EXIST-2

机译：依维莫司对结节性硬化症患者肾功能的影响：EXIST-1和EXIST-2的证据

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BackgroundA reduction in renal angiomyolipoma volume observed with everolimus (EVE) treatment in patients with tuberous sclerosis complex (TSC) has been postulated to translate to clinical benefit by reducing the risk of renal hemorrhage and chronic renal failure.

机译：背景依维莫司（EVE）治疗在结节性硬化症（TSC）患者中观察到的肾血管平滑肌脂肪瘤体积减少被认为可通过降低肾出血和慢性肾衰竭的风险转化为临床获益。

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期刊名称 Nephrology Dialysis Transplantation
作者
John J Bissler; Klemens Budde; Matthias Sauter; David N Franz; Bernard A Zonnenberg; Michael D Frost; Elena Belousova; Noah Berkowitz; Antonia Ridolfi; J Christopher Kingswood;
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作者单位

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年(卷),期 -1(34),6
年度 -1
页码 1000–1008
总页数 9
原文格式 PDF
正文语种
中图分类泌尿科学（泌尿生殖系疾病）;小儿泌尿科学;肾疾病;移植;
关键词
mTOR inhibition renal function tuberous sclerosis;

机译：mTOR抑制;肾功能;结节性硬化;

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专利

1. The effect of everolimus on renal angiomyolipoma in patients with tuberous sclerosis complex being treated for subependymal giant cell astrocytoma: Subgroup results from the randomized, placebo-controlled, Phase 3 trial EXIST-1 [J] . KingswoodJ.C., JozwiakS., BelousovaE.D., Nephrology, dialysis, transplantation: official publication of the European Dialysis and Transplant Association - European Renal Association . 2014,第6期

机译：依维莫司对正在治疗表皮下巨大细胞星形细胞瘤的结节性硬化症患者的肾血管平滑肌脂肪瘤的影响：亚组来自于随机，安慰剂对照的3期试验EXIST-1
2. Commentary on: Everolimus for angiomyolipoma associated with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis (EXIST-2): A multicentre, randomised, double-blind, placebo-controlled trial [J] . BlackP. Urology . 2013,第2期

机译：依维莫司治疗伴有结节性硬化症或散发性淋巴血管平滑肌瘤病（EXIST-2）的血管平滑肌脂肪瘤：一项多中心，随机，双盲，安慰剂对照试验
3. Everolimus for angiomyolipoma associated with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis (EXIST-2): A multicentre, randomised, double-blind, placebo-controlled trial [J] . BisslerJ.J., KingswoodJ.C., RadzikowskaE., The Lancet . 2013,第9869期

机译：依维莫司治疗伴有结节性硬化症或散发性淋巴管平滑肌肌瘤病（EXIST-2）的血管平滑肌脂肪瘤：一项多中心，随机，双盲，安慰剂对照试验
4. Machine Learning in Epilepsy Drug Treatment Outcome Prediction Using Multi-modality Data in Children with Tuberous Sclerosis Complex [C] . Jun Yang, Cailei Zhao, Shi Su, International Conference on Big Data and Information Analytics . 2020

机译：机器学习在癫痫药物治疗结果预测中使用肿瘤硬化复合体儿童的多种形态数据预测
5. Regulation and function of tuberous sclerosis complex-2 tumor suppressor in renal cell carcinoma. [D] . Liu, Yu. 2004

机译：肾细胞癌中结节性硬化复合物2肿瘤抑制因子的调节和功能。
6. The effect of everolimus on renal angiomyolipoma in patients with tuberous sclerosis complex being treated for subependymal giant cell astrocytoma: subgroup results from the randomized placebo-controlled Phase 3 trial EXIST-1 [O] . J. Chris Kingswood, Sergiusz Jozwiak, Elena D. Belousova, -1

机译：依维莫司对正在治疗表皮下巨细胞星形细胞瘤的结节性硬化症患者的肾血管平滑肌脂肪瘤的影响：亚组来自于随机安慰剂对照的3期临床试验EXIST-1
7. The effect of everolimus on renal angiomyolipoma in patients with tuberous sclerosis complex being treated for subependymal giant cell astrocytoma: subgroup results from the randomized, placebo-controlled, Phase 3 trial EXIST-1 [O] . J. C. Kingswood, S. Jozwiak, E. D. Belousova, 2014

机译：血对血模秋对患有子宫状巨型细胞星形细胞瘤治疗肿瘤硬化复合症患者肾血管眼球疟疾的影响：随机，安慰剂控制，第3阶段试验的亚组结果 - 1

Effect of everolimus on renal function in patients with tuberous sclerosis complex: evidence from EXIST-1 and EXIST-2

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